Mannose-6-phosphate receptor independent pathways of lysosome biogenesis and Mucolipidosis type II (MLII)

Judith Klumperman

Dr. Klumperman made her doctoral studies at the Laboratory for Electron Microscopy, University of Leiden in the Netherlands in 1989. She worked as a Post-doctoral fellow at the Department of Cell Biology, University Medical Center Utrecht (UMCU) in the Netherlands until 1992 and later at the Department of Molecular and Cellular Neurobiology at the Free University of Amsterdam as Junior staff member until 1997. Since 2001, Dr Klumperman is a full Professor in Cell Biology and Head of the Cell Microscopy Center at the Department of Cell Biology of the UMCU.

The main topics of interest of the Klumperman lab are the organization of biosynthetic and endocytic intracellular trafficking pathways and the regulatory mechanisms involved in intracellular protein transport by linking molecular to morphological information. Her team studies the general concepts of protein transport in the cell and how these are adapted in specialized cells. She also uses correlative live cell imaging and immuno-electron microscopy to study diseases that are related to defects intracellular transport (such as lysosomal disorders and certain types of cancers).