Manipulation of membrane trafficking pathways by Salmonella effector proteins.

Paul Pryor

Dr Pryor received his PhD in cell biology from the University of Bath in 2000. He then moved to the University of Cambridge to undertake his post-doctoral studies in the laboratory of Prof Paul Luzio, researching the molecular mechanisms for the delivery of proteins to lysosomes. Dr Pryor was then awarded a Wellcome Trust Career Development Fellowship in 2006 held at the University of York, investigating how pathogens manipulate membrane trafficking pathways. Dr Pryor has recently been appointed a lecturer in Cellular Microbiology at the Hull York Medical School.

The main focus of Dr Pryor's research is the delivery of exogenous material to the lysosome. Lysosomes are acidic organelles whose primary role is the degradation of material delivered to them and therefore they form part of our innate immunity. Current research involves understanding how bacteria and parasites are phagocytosed but survive intracellularly by manipulating the host's membrane trafficking pathways to avoid/delay delivery to the lysosome and thereby create their replicative niche.